दीनदयाल उपाध्याय गोरखपुर विश्वविद्यालय
Deen Dayal Upadhyaya Gorakhpur University
(Accredited A++ by NAAC)
Dr. Mahendra Pratap Singh
Ph.D., Associate Professor
Department of Zoology
1. Xenobiotics induced neurodegenerative diseases like Parkinson's and Alzheimer's diseases using Drosophila model & modulation through nutraceuticals. 2. Evaluation of Micro/Nano plastics and Green Engineered Nanoparticles on in vivo animal models. 3. The use of ethnomedicine to treat drug-induced liver damage in mammalian models.
| S.No. | Employer | Designation | From | To |
|---|---|---|---|---|
| 1 | DDU Gorakhpur University, Gorakhpur-273009, UP, India | Associate Professor | 23.11.2022 | Till date |
| 2 | Lovely Professional University, Phagwara, Punjab | Professor | 01.09.2022 | 22.11.2022 |
| 3 | Lovely Professional University, Phagwara, Punjab | Associate Professor | 01.08.2019 | 31.08.2022 |
| 4 | Lovely Professional University, Phagwara, Punjab | Assistant Professor | 06.01.2016 | 31.07.2019 |
| 5 | Yeungnam University, College of Medicines, Daegu, South Korea | Postdcotoral Fellow | 11.06.2013 | 30.04.2015 |
| 6 | Tulane University, School of Medicines, New Orleans, LA, USA | Postdoctoral Fellow | 18.05.2012 | 30.11.2012 |
| 7 | University of Nebraska-Lincoln, NE, USA | Postdoctoral Research Associate | 01.06.2010 | 17.05.2012 |
| S.No. | Title | Journal | Volume | Year | Contribution |
|---|---|---|---|---|---|
| 1 | The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease | Frontiers in Bioscience-Landmark | 30 | 2025 | Corresponding Author |
| 2 | Impact of Polyethylene Terephthalate Microplastics on Drosophila melanogaster Biological Profiles and Heat Shock Protein Levels | Biology | 13 | 2024 | Corresponding Author |
| 3 | Role of nutraceutical against exposure to pesticide residues: power of bioactive compounds | Frontiers in Nutrition | 11 | 2024 | Corresponding Author |
| 4 | Optimized QuEChERS Methodology for Reliable LC-MS/MS Quantification of Sertraline and Fluoxetine Hydrochloride in Biological Samples. | Natural Resources for Human Health | 1 | 2024 | Co-author |
| 5 | Phytofabrication, characterization of silver nanoparticles using Hippophae rhamnoides berries extract and their biological activities. | Frontiers in Microbiology | 15 | 2024 | Corresponding Author |
| 6 | Inferring microarray datasets reveals critical biomarkers and potential drug targets of Parkinson’s disease | Neurology Asia | 29 | 2024 | Co-author |
| 7 | Investigation of the Protective Effects of Urtica dioica, Capsella bursa-pastoris and Inula racemosa on Acetaminophen-Induced Nephrotoxicity in Swiss Albino Male Mice. | Applied Sciences | 13 | 2023 | Corresponding Author |
| 8 | The Ethnopharmacological Properties of Green-Engineered Metallic Nanoparticles against Metabolic Disorders | Medicina | 59 | 2023 | Corresponding Author |
| 9 | . Metabolic and Phenotypic Changes Induced during N-Acetylglucosamine Signalling in the Fungal Pathogen Candida albicans. | Biomedicines | 11 | 2023 | Co-author |
| 10 | Therapeutic Potential of Green-Engineered ZnO Nanoparticles on Rotenone-Exposed D. melanogaster (Oregon R+): Unveiling Ameliorated Biochemical, Cellular, and Behavioral Parameters | Antioxidants | 12 | 2023 | Corresponding Author |
| 11 | Toxicological Profile of Polyethylene Terephthalate (PET) Microplastic in Ingested Drosophila melanogaster (Oregon R+) and Its Adverse Effect on Behavior and Development. | Toxics | 11 | 2023 | Corresponding Author |
| 12 | The evidence of in-vivo and in-vitro studies on microplastic and nano plastic toxicity in mammals: A possible threat for an upcoming generation | Physics and Chemistry of the Earth | 132 | 2023 | Corresponding Author |
| 13 | A Comparative account on Antioxidant Activities, Total Phenolic and Flavonoid Contents of Punica granatum, Carica papaya, Foeniculum vulgare, Trigonella foenum-graecum, and Urtica dioica: An In Vitro Evaluation | Research Journal of Pharmacy and Technology | 15 | 2022 | Corresponding Author |
| 14 | Adverse effects of textile dyes on antioxidant enzymes and cholinesterase activities in Drosophila melanogaster (Oregon R+). | Drug and Chemical Toxicology | 45 | 2022 | Co-author |
| 15 | Contributive role of hyperglycemia and hypoglycemia toward the development of Alzheimer’s Disease. | Molecular Neurobiology | 59 | 2022 | Corresponding Author |
| 16 | Protection against drug-induced liver injuries through nutraceuticals via amelioration of Nrf-2 signaling. | Journal of the American Nutrition Association | 42 | 2022 | Corresponding Author |
| 17 | Ethnopharmacological effects of Urtica dioica, Matricaria chamomilla, and Murraya koinegii on rotenone exposed D. melanogaster: An attenuation of cellular, biochemical and organismal markers | Antioxidants | 11 | 2022 | Corresponding Author |
| 18 | Influence of the gut microbiota on the development of neurodegenerative diseases | Mediators of Inflammation | 2 | 2022 | First Author |
| 19 | 2 Hydroxyflavanone: A bioactive compound that protects against cancers | Applied Sciences | 12 | 2022 | Corresponding Author |
| 20 | Therapeutic antiaging strategies | Biomedicines | 10 | 2022 | Co-author |
| 21 | Protection of Phyto extracts against rotenone-induced organismal toxicities in Drosophila melanogaster via Attenuation of ROS generation. | Applied Sciences | 12 | 2022 | Corresponding Author |
| 22 | Proteinopathies: Deciphering Physiology and Mechanisms To Develop Effective Therapies For Neurodegenerative Disease | Molecular Neurobiology | 12 | 2022 | Corresponding Author |
| 23 | Impact of Altering the Ratio of Black Tea Granules and Ocimum gratissimum Leaves in a Binary Infusion on Radical Scavenging Potential Employing Cell Free Models and Ex Vivo Assays. | Applied Sciences | 12 | 2022 | Corresponding Author |
| 24 | Synthesis of Green Engineered Silver Nanoparticles through Urtica dioica: An Inhibition of Microbes and Alleviation of Cellular and Organismal Toxicity in Drosophila melanogaster | Antibiotics | 11 | 2022 | Corresponding Author |
| 25 | Appraisal of the Antioxidant Activity, Polyphenolic Content, and Characterization of Selected Himalayan Herbs: Anti-Proliferative Potential in HepG2 Cells. | Molecules | 27 | 2022 | Corresponding Author |
| 26 | Comparative role of nutraceuticals on chlorpyrifos induced neurotoxicity in Drosophila melanogaster | Toxicology International | 28 | 2021 | Corresponding Author |
| 27 | Generation of neurodegenerative phenotype using Drosophila melanogaster through paraquat treatment and amelioration by Tinospora cordifolia (giloy). | Research Journal of Pharmacy and Technology | 14 | 2021 | Corresponding Author |
| 28 | Ameliorative role of nutraceuticals on neurodegenerative diseases using the Drosophila melanogaster as a discovery model to define bioefficacy. | Journal of the American Nutrition Association | 41 | 2021 | Corresponding Author |
| S.No. | Name of Award | Agency | Year |
|---|---|---|---|
| 1 | Associate Editor | Frontiers in Nutrition | 2024 |
| 2 | University Research Excellence Award 2024 | DDU Gorakhpur Uninversity | 2024 |
| 3 | Guest Editor | Symmetry (MDPI) | 2023 |
| 4 | Associate Editor | Frontiers in Aging Neuroscience | 2022 |
| 5 | Guest Editor | Applied Sciences (MDPI) | 2022 |
| 6 | Guest Editor | Biomedicines (MDPI) | 2022 |
| 7 | Research Appreciation Award | Lovely Professional University | 2018 |
| 8 | Research Appreciation Award | Lovely Professional University | 2017 |
| S.No. | Title | Publisher | ISBN | Year |
|---|---|---|---|---|
| 1 | Benzene, Toluene and Xylene Induced Cytotoxicity in Drosophila | Scholar Press, Germany | 978-3- 639-71807-2 | 2014 |
| S.No. | Title | Patent Number | Year of Filing/Award/Published |
|---|---|---|---|
| 1 | Copyright on Literary/ dramatic work the purpose of study is to present the Toxicological profile of Polyethylene terephthalate (PET) using Drosophila melanogaster as an in vivo model. | L-134989/2023 | 2023 |
| 2 | Copyright on Literary/ dramatic work the purpose of study is to present the hepatoprotective effects of medicinal plants in mice via nrf2 signaling | L-130381/2023 | 2023 |
| 3 | Copyright on Literary/ dramatic work the graphical abstract present the fabrication of green engineered zinc oxide nanoparticles and its therapeutic biomedical applications | L-127809/2023 | 2023 |
| 4 | Copyright on Literary/ dramatic work the graphical abstract present the therapeutic applications of phyto nanotechnology for the treatment of neurodegeneration | L-130386/2023 | 2023 |
| 5 | Copyright on Literary/ dramatic work the graphical abstract entitled as “present the Cellular, biochemical and molecular studies On neurodegenerative diseases using Drosophila melanogaster: an alternate via Nutraceuticals | L-130476/2023 | 2023 |
| S.No. | Name | Contact Details Year of Enrollment |
Type of Scholar | Topic | Research Status |
|---|---|---|---|---|---|
| 1 | Dr. Palak Sharma | 0 na Enrollment Year: 2021 |
Research Scholar | Analysis of Anti Depressant Drugs in Forensic Matrices Using Instrumental Techniques. (Amity University, Noida) Awarded in 2024 | Completed |
| 2 | Dr. Shweta Siingh | 0 na Enrollment Year: 2021 |
Research Scholar | Investigation of binding capability of organic pesticides with biological receptors using experimental and computational approaches. (Amity University, Noida) Awarded in 2024 | Completed |
| 3 | Dr. Ranjana Himalian | NA NA |
Research Scholar | Cellular, biochemical and molecular studies on neurodegenerative diseases using Drosophila melanogaster: an alteration via nutraceuticals (PhD awarded in 2022 from LPU, Phagwara, Punjab) | Completed |
| 4 | Dr. Sumaira Yousuf | NA NA |
Research Scholar | Ameliorative effects of selected medicinal herbs on acetaminophen-induced hepatotoxicity in mice (PhD awarded in 2023 from LPU, Phagwara, Punjab) | Completed |
| 5 | Dr. Shabnam Shabir | NA NA |
Research Scholar | Studies on rotenone-induced neurodegeneration in Drosophila melanogaster and its modulation through green engineered nanoparticles (PhD awarded in 2023 from LPU, Phagwara, Punjab) Currently working as Assistant Professor at Lovely Professional University, Punjab) | Completed |
| S.No. | Title of Chapter | Page Numbers | Title of Book | Publisher | ISBN | Year |
|---|---|---|---|---|---|---|
| 1 | Nutraceuticals the prevention and treatment of Alzheimer's disease | 153-165 | A New Era in Alzheimer's disease | Elsevier (Academic Press) | 9780443155406 | 2024 |
| 2 | Unveiling the complexity of Alzheimer’s disease: Introduction and its pathophysiology | 1-15 | A New Era in Alzheimer's disease | Elsevier (Academic Press) | 9780443155406 | 2024 |
| 3 | Stem cell-based therapy as antiaging perspective | Chapter-14 | Anti-Aging Drug Discovery based on Hallmarks of Aging | Elsevier | 9780323902359 | 2022 |
| 4 | The aging: introduction, theories, principles, and future prospective. | Chapter-1 | Anti-Aging Drug Discovery based on Hallmarks of Aging | Elsevier | 9780323902359 | 2022 |
| 5 | Nanoparticles: Sources and Toxicity Nanomaterials and physiological and biochemical responses of plants” | 217-232 | Plant Responses to Nanomaterials | Springer International Publishing | 978-3-030-36740-4_9 | 2021 |
| 6 | Heavy metal contamination in water and its possible sources. | 179-189 | Heavy Metals in the Environment | Elsevier | 978-0-12-821656-9.00010-9 | 2021 |
| 7 | Genomics and Genetic Engineering of Rice for Resistance to Different Insect Pests. | 107-127 | Rice Research for Quality Improvement: Genomics and Genetic Engineering | Springer, Singapore | . https://doi.org/10.1007/978-981-15-5337-0_6. | 2021 |
| 8 | Monocyclic Aromatic Hydrocarbons (MAHs) Induced Toxicity in Drosophila: How Close How Far? | 1-8 | Trends in Insect Molecular Biology | Springer International Publishing | 978-3-319-61342-0 | 2018 |
| 9 | Mechanisms of Gene Transcriptional Regulation through Biotin and Biotin-Binding Proteins in Mammals. | 219-231 | Vitamin-Binding Proteins: Functional Consequences | CRC Press | 9781439880166 | 2013 |
| 10 | Biochemistry of biotin. | 146-157 | Food and Nutritional Components in Focus No. 4 | Royal Society of Chemistry, London, UK | 978-1849733694 | 2013 |